Heart problems have touched many of our lives, or the lives of those we care about. Heart attacks and heart failure are leading killers in the U. Typically, a heart attack is followed by significant heart muscle cell death, leaving the organ in a weakened state and the patient at risk of cardiovascular dysfunction and eventual heart failure.
This leads to many of the deaths attributed to cardiovascular disease. Over the past 20 years, hope has grown around the use of stem cells to enhance regeneration following a heart attack, wherein stem cells would facilitate tissue repair and help restore heart muscle function. This notion has captured the hope of many scientists and physicians, evidenced by the emergence of several companies e. However, the legitimacy of cardiac stem cell research is now being called into question. Allegations against one of the leading scientists in this field, Dr.
- 1. Introduction.
- 1. Introduction.
- The Mechanics of Intrusion of the Black Hills (S. D.) Precambrian Granite.
- An overview.
- Mini Review ARTICLE.
- Guide to Teaching Puzzle-based Learning (Undergraduate Topics in Computer Science)!
- Step-Up to Surgery (Step-Up Series).
These events will undoubtedly impact the field of cardiac stem cells. Those involved will need to find a way to overcome damaged perceptions and regain the trust of funders, investors, the academic community, and, most importantly, patients. Although the events leading to this situation are unique, three important lessons can be taken from this cautionary tale and applied across the field of stem cell research, from academia to biotech and pharma:.
Despite this, cardiac stem cell research accelerated quickly toward clinical trials, as scientists were understandably keen to get this potential new therapy to patients.
- Beginning J2ME: From Novice to Professional?
- Reorganizing the Joint Chiefs of Staff: The Goldwater-Nichols Act of 1986 (Contributions in Military Studies);
- Harry Dodsons Practical Kitchen Garden: Personal Guide to Growing Vegetables and Fruit.
- Electromagnetic Compatibility for Device Design and System Integration;
- 1. Introduction.
- Cardiac Regeneration;
- Medifocus Guidebook on: Chronic Pancreatitis.
- Gene and Stem Cell Therapies!
- Disease Treatments;
- Offender rehabilitation : theory, research and practice.
- Indigenous Knowledge, Ecology, and Evolutionary Biology.
- What Is the Influence of the National Science Education Standards?: Reviewing the Evidence : A Workshop Summary.
- Windows Help & Advice (June 2016).
However, this rush to commercialize has unfortunately meant clinical trials are now underway when much of the underlying biology is still not well understood. This will most likely impact the perceptions of cardiac stem cell research and trials, therefore affecting funding and investment. Instead, researchers and life sciences firms in the area of stem cell research should allow a strong evidence base to grow in order to be confident in the scientific basis before testing therapeutic benefit in humans.
Heart Disease – A Closer Look at Stem Cells
These journals must reassess their processes to uncover why so many papers were published with fabricated data. However, this also shows the need for those who read and use published information to critically review and evaluate findings, even if they are presented in highly esteemed journals.
Investors and companies involved in stem cells therefore need to ensure they do their due diligence when entering a therapeutic or disease area and to take conflicting results seriously, as was not done in the case of cardiac stem cells. A key lesson from this series of events is the need to emphasize the importance of replicating and reproducing scientific findings, rather than just focusing on novel research. Skip to search form Skip to main content. These somewhat disappointing results should emphasize the need for translational research, with bidirectional feedback between the basic research laboratory and the clinical arena.
View on Nature. Alternate Sources. Save to Library. Create Alert. Share This Paper. Figures, Tables, and Topics from this paper.
Log in to Wiley Online Library
Figures and Tables. Citations Publications citing this paper.
Multipotent mesenchymal stromal cells: clinical applications and cancer modeling. Denis B. Buxton , Sonia I.
Imaging in cardiac cell-based therapy: in vivo tracking of the biological fate of therapeutic cells Hung Quoc Ly , John V. Frangioni , Roger J. Oestrogen promotes coronary angiogenesis even under normoxic conditions.
Permanent coronary artery occlusion: cardiovascular MR imaging is platform for percutaneous transendocardial delivery and assessment of gene therapy in canine model.